Article

APOE Genotype and Biological Sex Regulate Astroglial Interactions with Amyloid Plaques in Alzheimer’s Disease Mice

2022-09-02

Abstract excerpt

The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E ( APOE4 ). APOE genotype and biological sex are key modulators of microglial and astroglial function, which exert multiple effects on AD pathogenesis. Here we show astroglial interactions with amyloid plaques in the EFAD transgenic mouse model of AD. Using confocal microscopy, we observe...

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Literature Corpus work: 206f1432-bede-5f10-9de8-90938e0bb08f
DOI: 10.21203/rs.3.rs-2002470/v1

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