Article

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease Risk

2018-11-02

Abstract excerpt

Apolipoprotein E (ApoE) mediates clearance of circulating lipoproteins from blood by binding to ApoE receptors. Humans express three genetic variants, ApoE2, ApoE3, and ApoE4, that exhibit distinct ApoE receptor binding properties. In brain, ApoE is abundantly produced by activated astrocytes and microglia, and three variants differentially affect Alzheimer’s disease (AD), such that ApoE2 protects against, and Apo...

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Literature Corpus work: e66ee604-fd84-5099-909a-b5a53d8b1499
DOI: 10.1101/460899

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