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Article

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

Journal of neuroinflammation - 19 Jun 2014

Rodriguez Gustavo A, Tai Leon M, LaDu Mary Jo, Rebeck G William

Abstract excerpt

BACKGROUND: Having the apolipoprotein E4 (APOE-ϵ4) allele is the strongest genetic risk factor for the development of Alzheimer's disease (AD). Accumulation of amyloid beta (Aβ) in the brain is influenced by APOE genotype. Transgenic mice co-expressing five familial AD mutations (5xFAD) in the presence of human APOE alleles (ϵ2, ϵ3 or ϵ4) exhibit APOE genotype-specific differences in early Aβ accumulation,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24948358
DOI: 10.1186/1742-2094-11-111
PMCID: PMC4077554

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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