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Article

APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer's disease mice.

Journal of neuroinflammation - 1 Dec 2022

Stephen T L, Breningstall B, Suresh S, McGill C J, Pike C J

Abstract excerpt

The most significant genetic risk factor for developing late-onset Alzheimer's disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astroglial function, which exert multiple effects on AD pathogenesis. Here, we show astroglial interactions with amyloid plaques in the EFAD transgenic mouse model of AD. Using confocal microscopy, we...

Topics

Female
Male
Mice
Animals
Plaque, Amyloid
Astrocytes
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Genotype
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36457019
DOI: 10.1186/s12974-022-02650-4
PMCID: PMC9714101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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