Article

Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs myelination and alters neuronal activity

2024-11-21

Abstract excerpt

<title>Abstract</title> <p>Aging has a critical role in the development of neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. In the current study, we investigated the impact of aging on the brain through telomere shortening, a physiological change correlated with aging. Animals with shortened telomeres exhibit cognitive decline and exacerbated lipofuscinosis in the brain. Our singl...

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Literature Corpus work: 2035df1b-4282-5ab8-9296-ca41eb3b149e
DOI: 10.21203/rs.3.rs-5014333/v1

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