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The role of cellular senescence in neurodegenerative diseases

15 May 2024

Abstract excerpt

Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer's disease (AD) and Parkinson's disease. Different senescent cell populations secrete senescence-associated secretory phenotypes (SASP), including matrix metalloproteinase-3, interleukin (IL)-1α, IL-6, and IL-8, which can harm adjacent microglia. Moreover, these cells possess high expression levels of senescence hallmarks...

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Neuroinflammation and Neurodegeneration Mechanisms
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38744709
DOI: 10.1007/s00204-024-03768-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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