Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

Abstract excerpt

Along with a general decline in overall health, most chronic degenerative human diseases are inherently associated with increasing age. Age-associated cognitive impairments and neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases, are potentially debilitating conditions that lack viable options for treatment, resulting in a tremendous economic and societal cost. Most high-profile clinical...

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• Genetics, Aging, and Longevity in Model Organisms
• Neuroinflammation and Neurodegeneration Mechanisms
• Telomeres, Telomerase, and Senescence