Article

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration

2023-10-11

Abstract excerpt

<h4>Summary</h4> Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused by hematopoietic progenitors expressing MAPK activating mutations that differentiate into senescent myeloid cells th...

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Literature Corpus work: fd7582b1-3793-57d7-b2c0-1d9247bc6e5c
DOI: 10.1101/2023.10.10.561744

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