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Article

The translocation mechanism of P‐glycoprotein

19 Dec 2005

Abstract excerpt

Multidrug transporters are involved in mediating the failure of chemotherapy in treating several serious diseases. The archetypal multidrug transporter P-glycoprotein (P-gp) confers resistance to a large number of chemically and functionally unrelated anti-cancer drugs by mediating efflux from cancer cells. The ability to efflux such a large number of drugs remains a biological enigma and the lack of mechanistic...

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PMID: 16380120
DOI: 10.1016/j.febslet.2005.11.083

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