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Article

Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4

7 Sept 2023

Abstract excerpt

Multidrug resistance-associated protein 4 (MRP4) is an ATP-binding cassette (ABC) transporter expressed at multiple tissue barriers where it actively extrudes a wide variety of drug compounds. Overexpression of MRP4 provides resistance to clinically used antineoplastic agents, making it a highly attractive therapeutic target for countering multidrug resistance. Here, we report cryo-EM structures of multiple...

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PMID: 37683641
DOI: 10.1016/j.str.2023.08.014

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