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Article

The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid.

Nature communications - 28 Nov 2019

Khunweeraphong Narakorn, Szöllősi Daniel, Stockner Thomas, Kuchler Karl

Abstract excerpt

The human ATP-binding cassette transporter ABCG2 is a key to anticancer resistance and physiological detoxification. However, the molecular mechanism of substrate transport remains enigmatic. A hydrophobic di-leucine motif in the ABCG2 core separates a large intracellular cavity from a smaller upper cavity. We show that the di-leucine motif acts as a valve that controls drug extrusion. Moreover, the extracellular...

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Identifiers

PMID: 31780715
DOI: 10.1038/s41467-019-13302-2
PMCID: PMC6883074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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