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Article

Exploring movement and energy in human P-glycoprotein conformational rearrangement.

Journal of biomolecular structure & dynamics - 1 Mar 2019

Zhang Yue, Gong Weikang, Wang Yan, Liu Yang, Li Chunhua

Abstract excerpt

Human P-glycoprotein (P-gp), a kind of ATP-Binding Cassette transporter, can export a diverse variety of anti-cancer drugs out of the tumor cell. Its overexpression is one of the main reasons for the multidrug resistance (MDR) of tumor cells. It has been confirmed that during the substrate transport process, P-gp experiences a large-scale structural rearrangement from the inward- to outward-facing states....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29620438
DOI: 10.1080/07391102.2018.1461133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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