Article

Supercharging the calcium pump: Identification of an activation hotspot on SERCA by cryo-EM

2026-02-06

Abstract excerpt

<h4>ABSTRACT</h4> The sarco-endoplasmic reticulum Ca²⁺-ATPase (SERCA) is a ubiquitous P-type ATPase that restores cytosolic Ca 2+ to the sarco-endoplasmic reticulum. SERCA is essential for cardiac Ca 2+ cycling and cellular energy metabolism. Several small molecules enhance SERCA function and show promise in models of metabolic and cardiovascular diseases. However, the structural basis for SERCA activation has...

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Literature Corpus work: 267da48e-3b7f-5f1e-97fe-1b7d82645742
DOI: 10.64898/2026.02.05.703879

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