Article
Two interaction sites on mammalian adenylyl cyclase type I and II: modulation by calmodulin and G(betagamma).
The Biochemical journal - 15 Apr 2008
Diel Susanne, Beyermann Michael, Lloréns Juana María Navarro, Wittig Burghardt, Kleuss Christiane
Abstract excerpt
Mammalian ACs (adenylyl cyclases) are integrating effector molecules in signal transduction regulated by a plethora of molecules in either an additive, synergistic or antagonistic manner. Out of nine different isoforms, each AC subtype uses an individual set of regulators. In the present study, we have used chimaeric constructs, point mutations and peptide competition studies with ACs to show a common mechanism...
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