Article
The mechanisms of HAMP-mediated signaling in transmembrane receptors.
Structure (London, England : 1993) - 9 Mar 2011
Ferris Hedda U, Dunin-Horkawicz Stanislaw, Mondéjar Laura García, Hulko Michael, Hantke Klaus, Martin Jörg, Schultz Joachim E, Zeth Kornelius, Lupas Andrei N, Coles Murray
Abstract excerpt
HAMP domains mediate signal transduction in over 7500 enzyme-coupled receptors represented in all kingdoms of life. The HAMP domain of the putative archaeal receptor Af1503 has a parallel, dimeric, four-helical coiled coil structure, but with unusual core packing, related to canonical packing by concerted axial rotation of the helices. This has led to the gearbox model for signal transduction, whereby the...
Topics
- Adenylyl Cyclases
- Amino Acid Motifs
- Archaeal Proteins
- Archaeoglobus fulgidus
- Bacterial Proteins
- Chimerism
- Crystallization
- Crystallography, X-Ray
- Membrane Proteins
- Models, Molecular
- Mutation
- Mycobacterium
- Protein Structure, Tertiary