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Article

Auto-inhibition of adenylyl cyclase 9 (AC9) by an isoform-specific motif in the carboxyl-terminal region.

Cellular signalling - 1 Nov 2018

Pálvölgyi Adrienn, Simpson James, Bodnár Ibolya, Bíró Judit, Palkovits Miklós, Radovits Tamás, Skehel Paul, Antoni Ferenc A

Abstract excerpt

Trans-membrane adenylyl cyclase (tmAC) isoforms show markedly distinct regulatory properties that have not been fully explored. AC9 is highly expressed in vital organs such as the heart and the brain. Here, we report that the isoform-specific carboxyl-terminal domain (C2b) of AC9 inhibits the activation of the enzyme by Gs-coupled receptors (GsCR). In human embryonic kidney cells (HEK293) stably overexpressing...

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Identifiers

PMID: 30121334
DOI: 10.1016/j.cellsig.2018.08.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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