Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases.

The Journal of biological chemistry - 21 Aug 2015

Komolov Konstantin E, Bhardwaj Anshul, Benovic Jeffrey L

Abstract excerpt

G protein-coupled receptor kinases (GRKs) are members of the protein kinase A, G, and C families (AGC) and play a central role in mediating G protein-coupled receptor phosphorylation and desensitization. One member of the family, GRK5, has been implicated in several human pathologies, including heart failure, hypertension, cancer, diabetes, and Alzheimer disease. To gain mechanistic insight into GRK5 function, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Baculoviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalytic Domain

Share to Crystallography, X-Ray

Share to Protein Interaction Domains and Motifs

Share to Protein Structure, Secondary

Share to Recombinant Proteins

Share to Spodoptera

Source

Open in PubMed Open full text

Identifiers

PMID: 26032409
DOI: 10.1074/jbc.M115.647297
PMCID: PMC4543624

Genes

GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases.PMID 26032409Read ↗

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.Semantic proximity Read ↗

A predicted amphipathic helix mediates plasma membrane localization of GRK5.Semantic proximity Read ↗

Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability.Semantic proximity Read ↗

Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli.Semantic proximity Read ↗

Isoform Specific Regulation of Adenylyl Cyclase 5 by GβγSemantic proximity Read ↗

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia.Semantic proximity Read ↗

Adenylyl cyclase 9 as a molecular scaffold to dissect the regulatory mechanisms of membrane adenylyl cyclasesSemantic proximity Read ↗

G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence.Semantic proximity Read ↗

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.Semantic proximity Read ↗

The G protein database, GproteinDb.Semantic proximity Read ↗

Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a HydraSemantic proximity Read ↗

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of GαiSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.