Article

Allosteric inhibition of adenylyl cyclase type 5 by G-protein: a molecular dynamics study

2020-06-23

Abstract excerpt

Adenylyl cyclases (ACs) have a crucial role in many signal transduction pathways, in particular in the intricate control of cyclic AMP (cAMP) generation from adenosine triphosphate (ATP). Using homology models developed from existing structural data and docking experiments, we have carried out all-atom, microsecond-scale molecular dynamics simulations on the AC5 isoform of adenylyl cyclase bound to the inhibitory...

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Literature Corpus work: 05f051e5-7b8d-55d9-90ae-28522575ff52
DOI: 10.1101/2020.06.23.166710

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