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Article

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia.

Nature structural & molecular biology - 1 Aug 2024

Yen Yu-Chen, Li Yong, Chen Chun-Liang, Klose Thomas, Watts Val J, Dessauer Carmen W, Tesmer John J G

Abstract excerpt

The nine different membrane-anchored adenylyl cyclase isoforms (AC1-9) in mammals are stimulated by the heterotrimeric G protein, Gαs, but their response to Gβγ regulation is isoform specific. In the present study, we report cryo-electron microscope structures of ligand-free AC5 in complex with Gβγ and a dimeric form of AC5 that could be involved in its regulation. Gβγ binds to a coiled-coil domain that links the...

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Identifiers

PMID: 38589608
DOI: 10.1038/s41594-024-01263-0
PMCID: PMC11329361

Genes

ADCY5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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