Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

Abstract excerpt

The nine different membrane-anchored adenylyl cyclase isoforms (AC1-9) in mammals are stimulated by the heterotrimeric G protein Gα s , but their response to Gβγ regulation is isoform-specific. For example, AC5 is conditionally activated by Gβγ. Here, we report cryo-EM structures of ligand-free AC5 in complex with Gβγ and of a dimeric form of AC5 that could be involved in its regulation. Gβγ binds to a coiled-coi...

Topics

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• Adenylyl Cyclases
• Cryoelectron Microscopy
• GTP-Binding Protein beta Subunits
• GTP-Binding Protein gamma Subunits
• HEK293 Cells
• Models, Molecular
• Protein Conformation
• Protein Multimerization

Identifiers and source

Literature Corpus work

0c567aaf-b73a-52f9-8f8a-9e35bd5f278e

DOI

10.1101/2023.05.02.539090