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Lymphocyte activation gene 3 (Lag3) supports Foxp3 <sup>+</sup> Treg cell function by restraining c-Myc-dependent aerobic glycolysis

2023-02-13

Abstract excerpt

Lymphocyte activation gene 3 (Lag3) has emerged as the next-generation immune checkpoint molecule due to its ability to inhibit effector T cell activity. Foxp3 + regulatory T (Treg) cells, a master regulator of immunity and tolerance, also highly express Lag3. While Lag3 is thought to be necessary for Treg cell-mediated regulation of immunity, the precise roles and underlying mechanisms remain largely elusive. In...

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Literature Corpus work
1eca28c5-be6e-5255-adb1-fe9642731aa1
DOI
10.1101/2023.02.13.528371
Open publication

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Lymphocyte activation gene 3 (Lag3) supports Foxp3 <sup>+</sup> Treg cell function by restraining c-Myc-dependent aerobic glycolysisDOI 10.1101/2023.02.13.528371
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