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Article

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.

Nature communications - 14 Mar 2017

Downs-Canner Stephanie, Berkey Sara, Delgoffe Greg M, Edwards Robert P, Curiel Tyler, Odunsi Kunle, Bartlett David L, Obermajer Nataša

Abstract excerpt

Th17 and regulatory T (Treg) cells are integral in maintaining immune homeostasis and Th17-Treg imbalance is associated with inflammatory immunosuppression in cancer. Here we show that Th17 cells are a source of tumour-induced Foxp3+ cells. In addition to natural (n)Treg and induced (i)Treg cells that develop from naive precursors, suppressive IL-17A+Foxp3+ and ex-Th17 Foxp3+ cells are converted from...

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PMID: 28290453
DOI: 10.1038/ncomms14649
PMCID: PMC5355894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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