Article

The Glucose Transporter GLUT3 Controls Regulatory T Cell Function

2026-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Regulatory T (Treg) cells are central mediators of immune tolerance and are generally considered to rely predominantly on mitochondrial metabolism rather than glucose-driven glycolysis. To define the role of glucose metabolism in Treg cells, we investigated the contribution of the hexose transporters GLUT1 and GLUT3. Genetic ablation of GLUT1 in T cells or selectively in Treg cells had minimal i...

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Literature Corpus work: 5aa01474-ea98-55e2-8eb4-903085107713
DOI: 10.64898/2026.03.26.714439

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