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Article

Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells.

Frontiers in immunology - 1 Jan 2021

Lu Jingli, Liang Yan, Meng Haiyang, Zhang Ailing, Zhao Junjie, Zhang Chengliang

Abstract excerpt

Forkhead box protein 3 (Foxp3+)-expressing regulatory T (Treg) cells are a unique CD4+T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefore, alterations to the epigenetics and metabolism affect Treg cell development and function. Recent evidence reveals...

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Share to Cell Differentiation
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Epigenesis, Genetic

Share to Forkhead Transcription Factors

Share to Gene Expression Regulation, Enzymologic

Share to Lymphocyte Activation

Share to T-Lymphocytes, Regulatory

Source

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Identifiers

PMID: 34421930
DOI: 10.3389/fimmu.2021.728783
PMCID: PMC8374078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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