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Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming.

Immunity - 12 Nov 2024

Kim Dongkyun, Kim Giha, Yu Rongzhen, Lee Juyeun, Kim Sohee, Gleason Mia R, Qiu Kevin, Montauti Elena, Wang Li Lily, Fang Deyu, Choi Jaehyuk, Chandel Navdeep S, Weinberg Samuel, Min Booki

Abstract excerpt

Lymphocyte activation gene 3 (Lag3) is an inhibitory co-receptor expressed on activated T cells and has been proposed to regulate regulatory T (Treg) cell function. However, its precise modality and mechanisms remain elusive. We generated Treg cell-specific Lag3-mutant mouse models and found that Lag3 was essential for Treg cell control of autoimmunity. RNA sequencing analysis revealed that Lag3 mutation altered...

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PMID: 39236718
DOI: 10.1016/j.immuni.2024.08.008

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