Article

ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway

2023-04-03

Abstract excerpt

The balance of pro-inflammatory T helper type 17 (Th17) and anti-inflammatory T regulatory (Treg) cells is crucial in maintaining immune homeostasis in health and disease conditions. Differentiation of naïve CD4 + T cells into Th17/Treg cells is dependent upon T cell receptor (TCR) activation and cytokine signaling, which includes the kinase ITK. Signals from ITK can regulate the differentiation of Th17 and Treg...

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Literature Corpus work: 37d959d2-f242-5b7d-8cd3-12f313a03cd2
DOI: 10.1101/2023.04.01.535229

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