Article
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3.
Nature immunology - 1 Jun 2022
Grebinoski Stephanie, Zhang Qianxia, Cillo Anthony R, Manne Sasikanth, Xiao Hanxi, Brunazzi Erin A, Tabib Tracy, Cardello Carly, Lian Christine G, Murphy George F, Lafyatis Robert, Wherry E John, Das Jishnu, Workman Creg J, Vignali Dario A A
Abstract excerpt
Impaired chronic viral and tumor clearance has been attributed to CD8+ T cell exhaustion, a differentiation state in which T cells have reduced and altered effector function that can be partially reversed upon blockade of inhibitory receptors. The role of the exhaustion program and transcriptional networks that control CD8+ T cell function and fate in autoimmunity is not clear. Here we show that intra-islet CD8+...
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