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Integrative analysis identified the key role of LAG3 in T cell exhaustion in glioma

2025-11-17

Abstract excerpt

<title>Abstract</title> <p>Lymphocyte-activation gene 3 (LAG3) is an immune checkpoint expressed on the surface of T cells. We conducted a comprehensive molecular characterization and clinical analysis of LAG3 expression in gliomas. Across the CGGA and TCGA glioma datasets, we observed that LAG3 expression increased with higher glioma grade. Further investigation into the molecular subtypes revealed that LAG3 exh...

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Literature Corpus work
cd7a3882-cf68-595d-a848-56c180fc9e59
DOI
10.21203/rs.3.rs-7553633/v1
Open publication

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