Article
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
Nature immunology - 1 Nov 2015
De Rosa Veronica, Galgani Mario, Porcellini Antonio, Colamatteo Alessandra, Santopaolo Marianna, Zuchegna Candida, Romano Antonella, De Simone Salvatore, Procaccini Claudio, La Rocca Claudia, Carrieri Pietro Biagio, Maniscalco Giorgia Teresa, Salvetti Marco, Buscarinu Maria Chiara, Franzese Adriana, Mozzillo Enza, La Cava Antonio, Matarese Giuseppe
Abstract excerpt
Human regulatory T cells (T(reg) cells) that develop from conventional T cells (T(conv) cells) following suboptimal stimulation via the T cell antigen receptor (TCR) (induced T(reg) cells (iT(reg) cells)) express the transcription factor Foxp3, are suppressive, and display an active proliferative and metabolic state. Here we found that the induction and suppressive function of iT(reg) cells tightly depended on...
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