Article

Genes adapt to outsmart gene targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation

2020-04-24

Abstract excerpt

Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo . However, because different gene-disruption strategies use different mechanisms to disrupt genes, the strategies can result in diverse phenotypes in the resulting mouse model. To determine whether different gene-disruption strategies affect the phenotype of resulting mutant mice, we char...

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Literature Corpus work: 1ec6e583-cb55-5096-834e-69a6fb98ef14
DOI: 10.1101/2020.04.22.041087

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