Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.

Genome biology - 9 Jul 2020

Hosur Vishnu, Low Benjamin E, Li Daniel, Stafford Grace A, Kohar Vivek, Shultz Leonard D, Wiles Michael V

Abstract excerpt

BACKGROUND: Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the strategies can result in diverse phenotypes in the resulting mouse model. To determine whether different gene disruption strategies affect the phenotype of resulting mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Gene Targeting

Share to Membrane Proteins

Share to Mice, Knockout

Share to Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 32646486
DOI: 10.1186/s13059-020-02086-0
PMCID: PMC7350591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.PMID 32646486Read ↗

Genes adapt to outsmart gene targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translationSemantic proximity Read ↗

A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci.Semantic proximity Read ↗

A resource of targeted mutant mouse lines for 5,061 genesSemantic proximity Read ↗

Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse LinesSemantic proximity Read ↗

Universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporationSemantic proximity Read ↗

Progress towards completing the mutant mouse null resource.Semantic proximity Read ↗

Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.Semantic proximity Read ↗

Biological plasticity rescues target activity in CRISPR knock outs.Semantic proximity Read ↗

CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells.Semantic proximity Read ↗

Mouse mutants and phenotypes: accessing information for the study of mammalian gene function.Semantic proximity Read ↗

Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes.Semantic proximity Read ↗

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.