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Article

Unexpected consequences: exon skipping caused by CRISPR-generated mutations.

Genome biology - 14 Jun 2017

Sharpe Joshua J, Cooper Thomas A

Abstract excerpt

A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be null can express aberrant proteins. This new information allows enhanced quality control procedures to select the best mutant alleles generated by CRISPR/Cas9.Please see related Method article: https://www.doi.org/10.1186/s13059-017-1237-8.

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Identifiers

PMID: 28615035
DOI: 10.1186/s13059-017-1240-0
PMCID: PMC5470267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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