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Article

Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse Lines

2021-10-06

Abstract excerpt

The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for its increased capacity and flexibility to efficiently generate null alleles in the C57BL/6N strain. In addition to being a valuable novel and accessible research resource, the p...

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Identifiers and source

Literature Corpus work
0a90293e-3d64-5531-8ac7-6e2c0d4fa900
DOI
10.1101/2021.10.06.463037
Open publication

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Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse LinesDOI 10.1101/2021.10.06.463037
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