Genome editing for the reproduction and remedy of human diseases in mice.

Abstract excerpt

With the recent progress in genome-editing technologies, such as the CRISPR/Cas9 system, genetically modified animals carrying nucleotide substitutions or large chromosomal rearrangements can be produced rapidly and at low cost. Such genome-editing techniques have been applied in the generation of animal models, especially mice, for reproducing human disease mutations, such as single-nucleotide polymorphisms...

Topics

• Animals
• CRISPR-Cas Systems
• Chromosome Aberrations
• Disease Models, Animal
• Gene Editing
• Genetic Diseases, Inborn
• Genome-Wide Association Study
• Humans
• Mice
• Mutation
• Polymorphism, Single Nucleotide