Article
CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells.
G3 (Bethesda, Md.) - 7 Jul 2016
Bishop Kathleen A, Harrington Anne, Kouranova Evguenia, Weinstein Edward J, Rosen Clifford J, Cui Xiaoxia, Liaw Lucy
Abstract excerpt
Targeted gene mutation in the mouse is a primary strategy to understand gene function and relation to phenotype. The Knockout Mouse Project (KOMP) had an initial goal to develop a public resource of mouse embryonic stem (ES) cell clones that carry null mutations in all genes. Indeed, many useful novel mouse models have been generated from publically accessible targeted mouse ES cell lines. However, there are...
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