Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.

doi:10.1038/s41598-024-72418-8

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Article

Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.

Scientific reports - 30 Sept 2024

Elrick Hillary, Peterson Kevin A, Willis Brandon J, Lanza Denise G, Acar Elif F, Ryder Edward J, Teboul Lydia, Kasparek Petr, Birling Marie-Christine, Adams David J, Bradley Allan, Braun Robert E, Brown Steve D, Caulder Adam, Codner Gemma F, DeMayo Francesco J, Dickinson Mary E, Doe Brendan, Duddy Graham, Gertsenstein Marina, Goodwin Leslie O, Hérault Yann, Lintott Lauri G, Lloyd K C Kent, Lorenzo Isabel, Mackenzie Matthew, Mallon Ann-Marie, McKerlie Colin, Parkinson Helen, Ramirez-Solis Ramiro, Seavitt John R, Sedlacek Radislav, Skarnes William C, Smedley Damien, Wells Sara, White Jacqueline K, Wood Joshua A, Murray Stephen A, Heaney Jason D, Nutter Lauryl M J

Abstract excerpt

The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for its increased capacity and flexibility to efficiently generate null alleles in the C57BL/6N strain. In addition to being a valuable novel and accessible research resource, the...

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PMID: 39349521
DOI: 10.1038/s41598-024-72418-8
PMCID: PMC11443006

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