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Article

Co-transcriptional splicing regulates 3' end cleavage during mammalian erythropoiesis.

Molecular cell - 4 Mar 2021

Reimer Kirsten A, Mimoso Claudia A, Adelman Karen, Neugebauer Karla M

Abstract excerpt

Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To determine how co-transcriptional splicing is integrated with transcription elongation and 3' end formation in mammalian cells, we performed long-read sequencing of individual nascent RNAs and precision run-on sequencing (PRO-seq) during mouse erythropoiesis. Splicing was not accompanied by transcriptional pausing and was...

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Identifiers

PMID: 33440169
DOI: 10.1016/j.molcel.2020.12.018
PMCID: PMC8038867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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