Article

Genetic regulation of nascent RNA maturation revealed by direct RNA nanopore sequencing

2024-08-29

Abstract excerpt

Quantitative trait loci analyses have revealed an important role for genetic variants in regulating alternative splicing (AS) and alternative cleavage and polyadenylation (APA) in humans. Yet, these studies are generally performed with mature mRNA, so they report on the outcome rather than the processes of RNA maturation and thus may overlook how variants directly modulate pre-mRNA processing. The order in which t...

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Literature Corpus work: 34d881fc-0217-553f-a3d6-1f5816870e04
DOI: 10.1101/2024.08.29.610338

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