Article

Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic transcripts

2022-08-12

Abstract excerpt

Combinatorially, intron excision within a given nascent transcript could proceed down any of thousands of paths, each of which would expose different dynamic landscapes of cis-elements and contribute to alternative splicing. In this study, we found that post-transcriptional multi-intron splicing order in human cells is largely predetermined, with most genes spliced in one or a few predominant orders. Strikingly, t...

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Identifiers and source

Literature Corpus work: 797838eb-e97a-5ddf-b7f5-5521a32b03e1
DOI: 10.1101/2022.08.12.503515

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