The pathobiology of splicing.

doi:10.1002/path.2649

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The pathobiology of splicing.

The Journal of pathology - 1 Jan 2010

Ward Amanda J, Cooper Thomas A

Abstract excerpt

Ninety-four percent of human genes are discontinuous, such that segments expressed as mRNA are contained within exons and separated by intervening segments, called introns. Following transcription, genes are expressed as precursor mRNAs (pre-mRNAs), which are spliced co-transcriptionally, and the flanking exons are joined together to form a continuous mRNA. One advantage of this architecture is that it allows...

Topics

Alternative Splicing
Exons
Genes, Neoplasm
Genetic Predisposition to Disease
Genetic Therapy
Humans
Introns
Mutation
Neoplasms
RNA Splicing
RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 19918805
DOI: 10.1002/path.2649
PMCID: PMC2855871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics