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Article

The pathobiology of splicing.

The Journal of pathology - 1 Jan 2010

Ward Amanda J, Cooper Thomas A

Abstract excerpt

Ninety-four percent of human genes are discontinuous, such that segments expressed as mRNA are contained within exons and separated by intervening segments, called introns. Following transcription, genes are expressed as precursor mRNAs (pre-mRNAs), which are spliced co-transcriptionally, and the flanking exons are joined together to form a continuous mRNA. One advantage of this architecture is that it allows...

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Identifiers

PMID: 19918805
DOI: 10.1002/path.2649
PMCID: PMC2855871

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Source receipt: pubmed, retrieved 7 Sept 2026.

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