Article

The competition between splicing and 3′ processing shapes the human transcriptome

2025-08-19

Abstract excerpt

<h4>SUMMARY</h4> Eukaryotic pre-mRNA processing steps, including splicing and 3′ processing, are tightly coordinated, yet the underlying mechanisms remain incompletely understood. U1 snRNP has been proposed to inhibit 3′ processing at intronic polyadenylation (IPA) sites through a splicing-independent mechanism termed telescripting. In contrast, we discovered that disrupting splicing—by targeting various key comp...

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Literature Corpus work: b3cee3b2-ac41-5597-af00-1fb5ef204fe3
DOI: 10.1101/2025.08.19.671063

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