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Article

Genetic regulation of nascent RNA maturation revealed by direct RNA nanopore sequencing.

Genome research - 14 Apr 2025

Choquet Karine, Chaumont Louis-Philippe, Bache Simon, Baxter-Koenigs Autum R, Churchman L Stirling

Abstract excerpt

Quantitative trait loci analyses have revealed an important role for genetic variants in regulating alternative splicing (AS) and alternative cleavage and polyadenylation (APA) in humans. Yet, these studies are generally performed with mature mRNA, so they report on the outcome rather than the processes of RNA maturation and thus may overlook how variants directly modulate pre-mRNA processing. The order in which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39952678
DOI: 10.1101/gr.279203.124
PMCID: PMC12047268

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