Article

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

2024-08-06

Abstract excerpt

Physiological variability in pancreatic cell type gene regulation and the impact on diabetes risk is poorly understood. In this study we mapped gene regulation in pancreatic cell types using single cell multiomic (joint RNA-seq and ATAC-seq) profiling in 28 non-diabetic donors in combination with single cell data from 35 non-diabetic donors in the Human Pancreas Analysis Program. We identified widespread associati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c84cf4b3-4bce-5063-82fe-bcf8a5ef0b7f
DOI: 10.1101/2024.08.03.606460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes riskDOI 10.1101/2024.08.03.606460Read

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read

An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic IsletsSemantic proximity Read

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes riskSemantic proximity Read

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 DiabetesSemantic proximity Read

Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypesSemantic proximity Read

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetesSemantic proximity Read

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progressionSemantic proximity Read

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesSemantic proximity Read

Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signaturesSemantic proximity Read

Comparative Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Insights into Type 2 Diabetes GeneticsSemantic proximity Read

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease GenesSemantic proximity Read

An integrated map of cell type-specific gene expression in pancreatic isletsSemantic proximity Read