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Article

Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis.

The Journal of biological chemistry - 29 Jan 2010

Alkhouri Naim, Gornicka Agnieszka, Berk Michael P, Thapaliya Samjhana, Dixon Laura J, Kashyap Sangeeta, Schauer Philip R, Feldstein Ariel E

Abstract excerpt

Adipocyte death has been reported in both obese humans and rodents. However, its role in metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation associated with obesity has not been studied. We now show using real-time reverse transcription-PCR arrays that adipose tissue of obese mice display a pro-apoptotic phenotype. Moreover, caspase activation and adipocyte apoptosis were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19940134
DOI: 10.1074/jbc.M109.074252
PMCID: PMC2823448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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