Article
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Immunity - 16 Jun 2020
Tummers Bart, Mari Luigi, Guy Clifford S, Heckmann Bradlee L, Rodriguez Diego A, Rühl Sebastian, Moretti Julien, Crawford Jeremy Chase, Fitzgerald Patrick, Kanneganti Thirumala-Devi, Janke Laura J, Pelletier Stephane, Blander J Magarian, Green Douglas R
Abstract excerpt
Cell death pathways regulate various homeostatic processes. Autoimmune lymphoproliferative syndrome (ALPS) in humans and lymphoproliferative (LPR) disease in mice result from abrogated CD95-induced apoptosis. Because caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the roles of caspase-8 in cell death and inflammation. Here, we describe oligomerization-deficient...
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