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The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease

28 May 2021

Abstract excerpt

Necroptosis is an inflammatory form of lytic programmed cell death that is thought to have evolved to defend against pathogens. Genetic deletion of the terminal effector protein-MLKL-shows no overt phenotype in the C57BL/6 mouse strain under conventional laboratory housing conditions. Small molecules that inhibit necroptosis by targeting the kinase activity of RIPK1, one of the main upstream conduits to MLKL...

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PMID: 34071602
DOI: 10.3390/biom11060803

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