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Article

Macrophage Plg-RKT expression promotes diet-induced obesity and metabolic dysfunction-associated steatotic liver disease.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2026

Miles Lindsey A, Bai Hongdong, Chakrabarty Sagarika, Baik Nagyung, Zhang Yuqing, Parmer Robert J, Samad Fahumiya

Abstract excerpt

BACKGROUND: Plg-RKT is a transmembrane plasminogen receptor that enhances the activation of plasminogen to plasmin and localizes proteolytic activity of plasmin on the cell surface. OBJECTIVES: We investigated the role of Plg-RKT in high-fat diet (HFD)-induced obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: Mice deficient in Plg-RKT in macrophages (mPlg-RKT-/-) or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41077131
DOI: 10.1016/j.jtha.2025.09.020
PMCID: PMC12671604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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