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A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

2025-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Liver aging is characterized by chronic inflammation and metabolic dysfunction that contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Necroptosis, a form of inflammatory cell death, is activated in aging livers, and genetic ( Ripk3 -/- or Mlkl -/- mice) or pharmacological (RIPK1 inhibitor necrostatin-1s) inhibition of necroptosis attenuates l...

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Literature Corpus work
00ab19e0-5662-51e5-af69-3d015af0f52c
DOI
10.1101/2025.05.02.651782
Open publication

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A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging LiverDOI 10.1101/2025.05.02.651782
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