Article

Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD

2025-11-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of hepatocellular carcinoma (HCC), particularly in obesity, yet mechanisms linking hepatocyte dysfunction to tumorigenesis remain unclear. Mixed lineage kinase domain-like protein (MLKL), the effector of necroptosis, is elevated in MASLD, but its hepatocyte-intrinsic role in obesity-...

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Literature Corpus work: 936a4682-7f51-556d-aef4-3795d4502623
DOI: 10.1101/2025.11.26.690789

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