Article

The Role of the Key Effector of Necroptotic Cell Death, Mlkl, in Mouse Models of Disease

2021-05-05

Abstract excerpt

Necroptosis is an inflammatory form of lytic programmed cell death that is thought to have evolved to defend against pathogens. Genetic deletion of the terminal effector protein – MLKL – shows no overt phenotype in the C57BL/6 mouse strain under conventional laboratory housing conditions. Small molecules that inhibit necroptosis by targeting the kinase activity of RIPK1, one of the main upstream condui...

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Literature Corpus work: 2ef9263b-fa64-599b-8c4c-101c5ae9fcc3
DOI: 10.20944/preprints202105.0053.v1

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